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Featured Articles

May 28, 2019

Risk Factors for Delirium in the Hospital Setting

Acute confusional state, also known as delirium or encephalopathy, is so common in hospitals that it’s almost seen as routine by many hospital staff. Between 14 to 56 percent of all hospitalized patients develop confusion. Intubated patients in the intensive care unit have an even higher rate, reaching about 82 percent. While delirium is all too familiar to hospital workers, it is deeply unnerving and distressing to friends and family members. Read More

Trans-Catheter Aortic Valve Replacement Can Improve Outcomes in Low-Risk Surgical Patients

For patients with aortic stenosis that cannot be treated with medication, surgical (SAVR) and transcatheter (TAVR) aortic valve replacement can offer effective treatment. A new study, one of two on the topic released today at the American Association for Thoracic Surgery's 99th Annual Meeting, examines, for the first time, the effects of TAVR with a balloon-expandable valve for low-risk patients.950 patients with severe symptomatic aortic stenosis and low surgical risk participated in the randomized trial.  Read More

Closed ICU Model May Reduce Hospital-Acquired Infections

A closed intensive care unit (ICU) model, whereby a patient is evaluated and admitted under an intensivist and orders involving patient care are written by the ICU team, is associated with a reduction in certain types of hospital-acquired infections, according to a study presented at the American Thoracic Society 2019 International Conference. Read More

New Algorithm Uses Disease History to Predict Intensive Care Patients' Chances of Survival

Researchers from the University of Copenhagen and Rigshospitalet have used data on more than 230,000 intensive care patients to develop a new algorithm. Among other things, it uses disease history from the past 23 years to predict patients' chances of survival in intensive care units. Every year, tens of thousands of patients are admitted to intensive care units throughout Denmark. Determining which treatment is best for the individual patient is a great challenge.  Read More

  • May 16, 2019

    Outside Temperature Impacts MDRO Incidence in Climate-Controlled ICUs

    Even in climate-controlled health care units, the outside temperature can influence the indoor temperature, and these changes may impact the incidence of multidrug-resistant organisms, or MRDOs, researchers reported in Infection Control & Hospital Epidemiology. “It remains unclear why seasonality and associations with high temperatures are detected even in hospitals or hospital units with climate control,” Dayanna Conislla Limaylla, MSc, from the post-graduate program in collective health at São Paulo State University, and colleagues wrote. “To fill these gaps in our knowledge, we conducted a prospective ecological study in a teaching hospital in Brazil.” Read More

    A 1-2 Punch: How Alarm Surveillance Increases Safety and Reduces Fatigue

    An often-cited study at Johns Hopkins Hospital found that there is a daily average of 350 alarms per bed in hospital critical care units. That means that all day (and night) long, critical care nurses are fielding hundreds of audible alarms from infusion pumps, cardiac monitors, ventilators, and other bedside machines. These nearly constant alarms compete for a nurse’s attention and are not prioritized by criticality. Worst of all, the majority of the messages aren’t relevant or actionable. All the noise can lead to deadly consequences should a caregiver become desensitized and assume an alarm is false or misdirected.  Read More

    Sleep Quality, Wakefulness May Predict Successful Weaning from Mechanical Ventilation

    Critically ill patients who have higher levels of wakefulness and the same depth of sleep in both the left and right hemispheres of their brains are more likely to experience successful weaning from mechanical ventilation, according to a study published in the American Journal of Respiratory and Critical Care Medicine. “Patients under mechanical ventilation in intensive care units frequently suffer from severe sleep deprivation and, as a consequence, exhibit abnormal patterns of sleep or wakefulness, which explain in part the frequent development of delirium,” Laurent Brochard, MD, PhD, director of the critical care medicine division at the University of Toronto. Read More

    New Approach in Managing Patients With Septic Shock

    Sepsis remains the most common cause of vasodilatory shock worldwide. The mainstay of haemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure.This article, published in the journal Critical Care, proposes the concept of “broad spectrum vasopressors” as a new approach to the initial management of septic shock. Based on this strategy, patients with septic shock are started on multiple vasopressors with a different mechanism of action simultaneously while the vasopressor sensitivity is assessed. Read More

  • May 8, 2019

    How Well-Designed Tech Can Help Medical Professionals Avoid Burnout

    Right now, technology is diminishing clinician and patient experience. It could and should be improving them.How should doctors and nurses spend their time? Ideally, talking with patients about their pain and progress, examining their illnesses and injuries, and planning their treatment. But, that’s a shrinking part of clinicians’ days. Luckily, it's a reversible trend.A study by the University of Wisconsin last year determined that primary care physicians spend more than half of their working hours on administration such as updating health records, ordering tests and inputting billing codes. Read More

    Hospital ICU Patients with Non-Brain-Related Injuries May Have Undetected Cognitive Deficits

    A new study led by Western University and Lawson Health Research Institute has found that most patients entering hospital intensive care units (ICU) for non-brain-related injuries or ailments also suffer from some level of related cognitive dysfunction that currently goes undetected in most cases.The findings were published today in the influential scientific journal, PLOS ONE. Many patients spend time in the ICU for reasons that have nothing to do with a known brain injury, and most health care providers and caregivers don't have any evidence to believe there is an issue with the brain. For example, a patient may have had a traumatic injury that does not involve the brain, yet still requires breathing support to enable surgeons to fix damaged organs, they may have issues with their heart or lungs, they may contract a serious infection, or they may simply be recovering from a surgical procedure like an organ transplant that has nothing directly to do with their brain. Read More

    Drug-Free MRSA Treatment to be Tested in Clinical Studies

    Researchers have identified a drug-free approach to treating MRSA using blue light and hydrogen peroxide.“We found that blue light bleaches a pigment residing in the membrane of S. aureus,” Ji-Xin Cheng, professor of biomedical engineering and electrical and computer engineering at Boston University, told Infectious Diseases in Children. “This increases the permeability of the membrane, allowing hydrogen peroxide to enter bacteria and kill them.” Cheng and colleagues wrote that drug-free treatments for MRSA are needed because antibiotic resistance is outpacing the development of new antibiotics. Read More

    Intensive Care Cocoon Hospital Bed Aims to Relieve ICU Delirium in PatientsIntensive Care Cocoon Hospital Bed Aims to Relieve ICU Delirium in Patients

    A new intensive care cocoon developed by a Brisbane hospital aims to reduce "absolutely petrifying" delirium that occurs in up to 80 per cent of patients being treated in a hospital intensive care unit (ICU). ICU delirium is caused by multiple factors, but is exacerbated by the noise, light, and sleep deprivation experienced in an ICU. Former ICU patients say their lengthy stays in hospital left them with psychological scars long after they healed physically. The aim of the ICU cocoon is to provide a calmer and more secluded stay in hospital, using noise-cancelling technology and video screens. ICU delirium is a serious condition that results in an acute change in the mental state of critically ill patients, with disturbances to their consciousness, attention, cognition and perception. Read More

  • May 2, 2019

    Self-Care ‘Critically Important’ to Avoid Compassion Fatigue, Prevent Burnout

    Self-care is critically important for health care providers to avoid compassion fatigue and prevent burnout, according to a presenter at HOPA Ahead 2019. “The work we do exposes us to tremendous amounts of suffering and ‘what-if’ questions,” Justin N. Baker, MD, FAAP, FAAHPM, Baker, MD, FAAHPM, FAAP, chief of the division of quality of life and palliative care, director of the hematology/oncology fellowship program and full member of the department of oncology at St. Jude Children’s Research Hospital, said during a presentation. “The personal and professional impact of chronic patient death is profound. If we don’t talk about self-care, and if we don’t contemplate what the impact of doing this work every day has on each of us, we won’t be able to help [our patients].” Read More

    Taming Building Automation System Alarm Fatigue

    In hospitals all over the country, there exist extremely robust building automation systems (BAS), designed to provide constant monitoring of critical equipment. They are screaming for help, and no one is paying attention. It isn’t due to negligence or apathy. It is due to a condition known as alarm fatigue. Alarm fatigue is caused by two major oversights at the infancy of installation and design of the system. Read More

    Nebulized Antibiotics: What is Their Place in ICU infections?

    Inhaled antibiotics have been used as adjunctive therapy for patients with pneumonia, primarily caused by multidrug resistant (MDR) pathogens . Most studies have been in ventilated patients, although non-ventilated patients have also been included (but not discussed in this review), and most patients have had nosocomial pneumonia. Aerosolized antibiotics are generally added to systemic therapy, and have shown efficacy , primarily as salvage therapy for failing patients and as adjunctive therapy after an MDR gram-negative has been identified. An advantage to aerosolized antibiotics is that they can achieve high intra-pulmonary concentrations that are potentially effective , even for highly resistant pathogens, and because they are generally not well- absorbed systemically, it is possible to avoid some of the toxicities of systemic therapy. Read More

    Bathing Patients with an Antiseptic Reduces Bloodstream Infections

    Research Medical Center’s Dr. Olevia Pitts, center, explains the bathing protocol to a surgical patient. A common practice at hospitals is to ensure all patients bathe once a day with common soap and water to ward off infections. A 2013 study HCA participated in found bathing intensive-care unit patients with soap containing the antiseptic chlorhexidine cut the incidence of central line bloodstream infections by 44%. Read More

  • April 18, 2019

    Antibiotics Unnecessary in Coagulase-Negative Staphylococci Catheter-Related BSI

    Study findings indicated that withholding antimicrobial therapy in CoNS-CRBSI is neither associated with short-term complications nor with long-term recurrences. Patients not receiving antibiotics for catheter-related bloodstream infections (CRBSI) with coagulase-negative Staphylococci (CoNS) after catheter removal experience similar short-term complications and long-term recurrences to patients receiving ≥5 days of antibiotic therapy, according study results published in Antimicrobial Resistance & Infection Control. Read More

    ICU Patients with Non-Brain-Related Injuries May Suffer Undetected Cognitive Dysfunction

    Many patients spend time in the ICU for reasons that have nothing to do with a known brain injury, and most health care providers and caregivers don't have any evidence to believe there is an issue with the brain. For example, a patient may have had a traumatic injury that does not involve the brain, yet still requires breathing support to enable surgeons to fix damaged organs, they may have issues with their heart or lungs, they may contract a serious infection, or they may simply be recovering from a surgical procedure like an organ transplant that has nothing directly to do with their brain. Read More

    Study Provides Insight Into Use of Critical Care Resources

    A study by Massachusetts General Hospital (MGH) investigators has found wide variation in the use of different hospital units—intensive care or general medical units—to deliver a type of advanced respiratory support called non-invasive ventilation. The team's report published in Critical Care Medicine found no differences in length of stay or in-hospital deaths among patients with chronic obstructive pulmonary disease (COPD) receiving this treatment that were associated with whether they were treated on a general medical unit or an intensive care unit (ICU). Read More

    Study Says Hospital Acquired Infections Can Make Patients ‘Feel Like Lepers’

    Healthcare associated infections such as MRSA cause more than just physical distress for patients, according to a recent analysis. The study, published in the American Journal of Infection Control, a journal of the Association of Professionals in Infection Control and Epidemiology, found many patients had emotional responses to diagnoses of hospital acquired infections, including “feeling dirty,” “having the plague” or “feeling like a leper.” Researchers at Glasgow Caledonian University in Scotland conducted a meta-synthesis of qualitative research, according to a news release on the study. Read More

  • January 17, 2019

    Oral, Gut Decontamination Does Not Reduce Bloodstream Infections in ICU

    Results of a randomized clinical trial showed that selective oral or digestive tract decontamination is not associated with reductions in ICU-acquired bloodstream infections caused by multidrug-resistant gram-negative bacteria among patients receiving mechanical ventilation with moderate to high antibiotic resistance prevalence. Read More

    New Study Compares Performance of Real-Time Infectious Disease Forecasting Models

    In what the authors believe is the first documented comparison of several real-time infectious disease forecasting models by different teams across many seasons, five research groups report this week that a majority of models consistently showed higher accuracy than historical baseline models. Read More

    New AI Can Detect Urinary Tract Infections

    New AI developed at the University of Surrey could identify and help reduce one of the top causes of hospitalisation for people living with dementia: urinary tract infections (UTI). UTI is an infection of any part of the urinary system, from the kidneys to the bladder. The symptoms include pain in the lower part of the stomach, blood in urine, needing to urinate suddenly or more often than usual and changes in mood and behaviour. Read More

    CDC: Flu Cases Hit 7 Million in the United States

    The flu season is picking up steam, with about 7 million Americans having been struck by a strain of the flu virus, health officials said Friday. Almost half of those individuals went to a doctor, while 69,000 to 84,000 people have been hospitalized for flu-related illness, the U.S. Centers for Disease Control and Prevention said in a new release. As of Jan. 5, 15 states and New York City were reporting high flu activity, and it was widespread in 30 states. The influenza A strain H1N1 remains the most common type of flu. This strain has been circulating and was pandemic in 2009 and in 1918. Read More

  • January 10, 2019

    How Common Pain Relievers May Promote Clostridium Difficile Infections

    Clostridium difficile causes the most common and most dangerous hospital-born infections in the United States and around the world. People treated with antibiotics are at heightened risk because those drugs disturb the microbial balance of the gut, but observational studies have also identified a link between severe C. difficile infections and use of NSAIDs, or non-steroidal anti-inflammatory drugs.  Read More

    Plumbing Contamination Linked with Cluster of Infections from Rare Sphingomona Species

    Health care-associated infection (HAI) rates are down overall in the United States but remain a problem in health care settings. In 2015 there were an estimated 687,000 HAIs in US acute care hospitals, and 72,000 hospital patients with HAIs died during their hospitalizations. Although surgical site infections, pneumonia, and Clostridium difficile infections account for most HAIs, the NEJM study detailed a cluster of infections caused by waterborne Sphingomonas species, including S koreensis, an uncommon gram-negative bacterium that was first documented as a human pathogen in a 2015 study. Read More

    Characteristics of Skin, Soft Tissue Infections Requiring High-Level Care

    Data published in the Annals of Emergency Medicine identified a limited number of simple clinical characteristics that appear to identify skin and soft tissue infections that require high-level inpatient services. A noncurrent review of existing records identified emergency department patients treated for skin and soft tissue infections. The presence or absence of select criteria was recorded for each case, along with whether the patient needed high-level care (defined as intensive care unit admission, operating room surgical intervention, or death as the primary outcome). Recursive partitioning was then applied to identify the principal criteria associated with high-level care. Read More

    ICU Stethoscopes Harbor DNA from Nosocomial Bacteria

    Stethoscopes are often used on multiple patients, and have been considered as vectors for hospital-based bacterial contamination. In this study, the authors used molecular methods to investigate the bacterial status of stethoscopes used in medical ICUs, even those that are used only once, and whether conventional methods of cleaning stethoscopes effectively decontaminate them and, if not, what microbes may be found on them. Read More

  • November 8, 2018

    How Hospitals Can Prevent Dementia in ICU Patients

    A checklist that focuses on pain assessment and exercise can help reduce intensive care unit patients' risk of developing long-term mental effects, such as dementia and confusion, NPR reports. Four things to know: 1. Following the checklist can cut a patient's risk of mental impairment after an ICU stay by 25 percent to 30 percent, said Eugene Wesley Ely, MD, professor of medicine at Vanderbilt University School of Medicine in Nashville, Tenn. This post-ICU condition is different than memory problems that may arise after heart surgery and general anesthesia in the elderly. Read More

    Oral, Gut Decontamination Does Not Reduce Bloodstream Infections in ICU

    Results of a randomized clinical trial showed that selective oral or digestive tract decontamination is not associated with reductions in ICU-acquired bloodstream infections caused by multidrug-resistant gram-negative bacteria among patients receiving mechanical ventilation with moderate to high antibiotic resistance prevalence. [Selective decontamination of the digestive tract (SDD)] and [selective oropharyngeal decontamination (SOD)] are routinely used in ICUs in the Netherlands, but their use has not been widely adopted in other countries, mainly because of limited efficacy data in settings with higher levels of antibiotic resistance and concern about emergence of antibiotic resistance, although the latter is not supported by meta-analyses,” Bastiaan H. Wittekamp, MD, PhD, of University Medical Center Utrecht in the Netherlands, and colleagues wrote in JAMA. Read More

    Shoe Sole and Floor Contamination: A New Consideration in the Environmental Hygiene Challenge for Hospitals

    It sounds like the beginnings of a riddle: What do we wear and walk on daily but never truly think about, especially in terms of pathogen transmission? Shoe soles and healthcare facility floors are the workhorses of the environment, and yet their capacity for aiding and abetting infectious agents remains unclear. Recent research seems to confirm what common sense already tells us -- that items which contact the floor are contaminated and could serve as vectors; despite daily cleaning of high-touch surfaces such as floors, it has already been shown that bacterial and viral contamination returns rather quickly. Read More

    Machine-Learning System Could Aid Critical Decisions in Sepsis Care

    Researchers from MIT and Massachusetts General Hospital (MGH) have developed a predictive model that could guide clinicians in deciding when to give potentially lifesaving drugs to patients being treated for sepsis in the ER. Sepsis is one of the most frequent causes of admission, and one of the most common causes of death, in the intensive care unit. But the vast majority of these patients first come in through the ER. Treatment usually begins with antibiotics and intravenous fluids, a couple liters at a time. If patients don’t respond well, they may go into septic shock, where their blood pressure drops dangerously low and organs fail. Then it’s often off to the ICU, where clinicians may reduce or stop the fluids and begin vasopressor medications, such as norepinephrine and dopamine, to raise and maintain the patient’s blood pressure. Read More

  • October 31, 2018

    Predicting C. difficile: Researchers Identify Cluster of Factors

    A cluster of factors may help predict which patients are likely to develop Clostridioides difficile, a potentially life-threatening disease commonly known as C. difficile or C. diff, a new study has found. And that could help in efforts to prevent infection, according to the researchers. Read More

    Facebook 'Viable Method' for Implementing Critical Care Ultrasound Curriculum

    Critical care ultrasound (CCUS) is an important skill for all critical care physicians to understand. However, currently there is no standard approach to how to teach CCUS. Researchers aimed to investigate the feasibility of implementing a CCUS curriculum via a social platform in order to evaluate the impact it has on fellow's self-perceived competency. Results found that utilizing a social media platform, like Facebook, provides benefits such as spaced learning, active participation, and an informal and personal learning environment.  Read More

    Using Positive Deviance to Achieve Efficacy, Clarity in HAI Prevention

    The literature is replete with attempts to design and promote customized guidelines to reduce infections during the care continuum. Paradoxically, these efforts sometimes result in gray areas where many staff members are unaware of what is required of them, which then leads to confusion, frustration and uncertainty. Gesser-Edelsburg, et al. (2018) coined the phrase “gray areas” in this context to encompass the variety of situations on the care continuum that are not addressed in the accepted guidelines, and where staff members are unsure of how to proceed. Read More

    10 Hospital Objects That Breed Infection-Causing Bacteria

    Reader's Digest compiled a list of hospital objects that can hold large amounts of bacteria and other microbes, including elevator buttons, faucets and patient privacy curtains. Here are 10 hospital objects that have been found to breed infection-causing bacteria: 1. Privacy curtains. The privacy curtains that surround patients' beds can be contaminated with methicillin-resistant Staphylococcus aureus bacteria, according to a recent study. The researchers tracked the contamination of 10 freshly cleaned curtains. Within two weeks, about 90 percent of the curtains were colonized by MRSA bacteria. Read More

  • October 18, 2018

    Sink Traps are Surprising Source of Antibiotic-Resistant Bacteria in ICU

    During a nationwide outbreak of healthcare-associated infections of an antibiotic-resistant bacteria, an Israeli hospital traced repeated infections of patients in its intensive care unit (ICU) to an unexpected source--sink traps, according to a study published today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. Read More

    New Studies Illustrate Need for Rigorous Review of Infection Preventionist Staffing Models Across Healthcare Systems

    Severe gaps in staffing and outdated coverage benchmarks point to the critical need for evaluating and updating standards for infection preventionist (IP) staffing levels, according to two new studies that explored infection prevention and control resourcing across a variety of healthcare settings. The studies were published in the American Journal of Infection Control (AJIC), the journal of the Association for Professionals in Infection Control and Epidemiology (APIC).  Read More

    C. difficile Survives Commercial Laundering of Hospital Bedsheets

    Commercial washing and drying under United Kingdom health care laundry policy failed to remove all Clostridium difficile, also known as Clostridioides difficile, spores on hospital bedsheets, according to study results published in Infection Control & Hospital Epidemiology. Our research found that standard laundering methods in U.K. hospitals failed to remove all traces of C. difficile, suggesting that linens could be another source of infection among patients and even other hospitals,” Katie Laird, PhD, head of the infectious disease research group in the school of pharmacy at De Montfort University, told Infectious Disease News. “These findings are significant because they could provide an explanation for otherwise unknown C. difficile outbreaks.” Read More

    Sepsis Surveillance Limited by Variations in Claims Data

    An analysis of records from nearly 200 hospitals showed that variations in the completeness and accuracy of claims data makes it difficult to compare sepsis rates and outcomes, according to findings presented at IDWeek. Researchers said meaningful comparisons may require the use of objective clinical data to facilitate improved sepsis surveillance. Read More

  • October 11, 2018

    Impact of a Nurse Intervention to Improve Sleep Quality in Intensive Care Units: Results from a Randomized Controlled Trial

    Researchers conducted this pilot randomized controlled trial in Spain to assess the effect a brief nurse intervention on sleep quality in patients in the intensive care unit (ICU). For this investigation, 40 patients admitted in hospital for valve cardiac surgery were randomly allocated to the control group (n=20), receiving usual care, and to the experimental group (n=20), receiving a nurse intervention the day before surgery and admission in the ICU. The investigators found that patients’ sleep quality was not improved by nurse intervention prior to ICU admission. Read More

    Digital Tool Quantifies Nurses’ Intuition and Predicts Potential Critical Situations

    Nurses often talk about having a sixth sense. A gut feeling says something is wrong with a patient, but putting that intuition into words and validating it can be hard. Perhaps a patient isn’t eating or drinking as much as the day before or the texture of their skin changed slightly. Maybe yesterday their mind was clear and today they are confused. These subtle changes could be early signs of a person’s health deteriorating, and they are picked up by a digital tool called the Rothman Index.  Read More

    Complexity of Work Environment Limits Nurses from Achieving a Healthy Lifestyle

    Research among nurses reports fewer than 10 percent meet physical activity guidelines and eat a healthy diet. The American Nurses Association underscored this issue by declaring 2017 as the Year of the Healthy Nurse. A new study published in the Journal of Nutrition Education and Behavior found that despite providing pedometers, a smartphone app, and access to a Facebook group, study participants were unable to change their diet and physical activity levels at the same time. Read More

    Early Dialysis Not Better for Septic Shock Patients with Acute Kidney Injury

    Early renal replacement therapy for patients in the initial phase of septic shock who have severe acute kidney injury is no better than delayed therapy, according to a French study of 488 patients that was stopped early for futility. After 90 days, 58% in the early treatment group had died vs 54% among patients whose treatment was delayed 48 hours to see if renal recovery would occur. In many cases, kidney function returned spontaneously. Results of the study, a multicenter, randomized trial known as IDEAL-ICU, were published online October 10 in the New England Journal of Medicine. Read More

  • October 3, 2018

    Severe Infections Rising Among Americans with Diabetes

    The number of Americans with diabetes who wind up in hospitals with serious infections, or who develop them while in the hospital, is on the rise. Between 2010 and 2015, the number of diabetics hospitalized for infections rose 52 percent (from 16 per 1,000 people to 24 per 1,000), according to researchers from the U.S. Centers for Disease Control and Prevention. "People with diabetes are more susceptible to in-hospital infections as compared with people without diabetes, and this risk is increasing," said lead researcher Jessica Harding, from the CDC's Division of Diabetes Translation. Read More

    Opt-Out Testing for HIV, Hepatitis C Could Improve Diagnoses in the ED

    A new study from screening results performed at a pair of Oakland-based hospital systems found that automated, routine testing for HIV and hepatitis C virus (HCV) conducted in integration with standard nursing workflow could increase the prevalence of caught diagnoses for both diseases. The obvious end-result would be more timely care for patients unlikely to be tested outside of an emergency department (ED) setting—namely, younger patients. Read More

    Study Explores Impact of Hand-Drying Method on Contamination and Bacteria Levels in Hospital Washrooms

    Laboratory and in situ studies have demonstrated that some hand drying methods are associated with a greater risk of dissemination of residual microbes from hands after (especially suboptimal) handwashing. In this latest study, supported by a grant from ETS, two toilets per hospital were observed – each had paper towel dispensers and jet air hand dryers, but only one of these was available to use at any given time – the hand drying method was changed every four weeks. The toilets were frequented by patients, visitors and staff. Bacterial contamination levels were measured over 12 weeks. Target bacteria included methicillin susceptible (MSSA) and resistant Staphylococcus aureus (MRSA), enterococci and enterobacteria, including ESBL (extended-spectrum β-lactamase) bacteria. Read More

  • September 25, 2018

    Recent Developments in Surgical Sepsis

    It is almost a century since Moynihan famously noted that, “every surgical operation is an experiment in bacteriology.” While the basic components of that experiment (the host, the bacterial flora and the factors which alter the balance between bacterial capacity for invasion and host resistance) have not changed, the outcome of surgical procedure, even when complicated by infection, has improved markedly. Read More

    Cath Lab Pre-Activation Beneficial But Not Routine in STEMI

    Fewer than half of patients with STEMI who were transported by emergency medical services had catheterization laboratory pre-activation before they arrived at the hospital, despite a suggestion of mortality benefit from cath lab pre-activation, according to a study published in JACC: Cardiovascular Interventions. Read More

    Hospitals Could Reduce HAIs by up to 55%

    A large systematic review and meta-analysis showed that hospitals could reduce health care-associated infections, or HAIs, by 35% to 55% with systematic implementation of evidence-based infection prevention and control measures.
    The findings were published in Infection Control & Hospital Epidemiology.
    Read More

    Biomarker-Guided Antimicrobial Stewardship: The Next Target, or Missing the Mark?

    Sepsis is a common and serious condition that can lead to significant morbidity and mortality. Because early and effective antibiotic therapy is a critical component of treatment, there is ongoing interest in increasingly rapid and reliable diagnosis. In conjunction with clinical evaluation, biomarkers have emerged as potentially useful diagnostic tools and may additionally have a role later in therapy to evaluate clinical response and guide cessation of antibiotics. Read More